According to a commentary, several issues still need to be addressed. One is the relationship between alcohol use disorders and related comorbidities as alcohol use disorders are probably associated with poor diet and lifestyle, smoking, cardiovascular comorbidity, lower adherence to medical treatments, depression, and potentially social isolation. It notes that the researchers used a crude, area-based measure of socioeconomic status, and exploration of this aspect of the relationship between alcohol use disorders and dementia in more detail will be important. Additional questions relate to the threshold of alcohol consumption and potential cross-cultural differences. Although many questions remain, the commentators suggest several can be answered using existing data, which would provide an opportunity to refine understanding of the pathways of modifiable risk and develop optimal prevention strategies.