The starting dose is 5 mg once daily, and depending on assessment of tolerability after 6 months, the dose can be increased to 10 mg once daily to achieve optimal response. Limited data exist in patients with moderate to severe hepatic impairment. The recommended starting dosage for moderate (Child-Pugh Class B) and severe (Child-Pugh Class C) hepatic impairment is 5 mg once weekly. No dose adjustment is needed for mild hepatic impairment (Child-Pugh Class A).