In the study, patients given Xofigo with abiraterone acetate (Zytiga) and prednisone/prednisolone died on average 2.6 months earlier vs placebo with abiraterone acetate and prednisone/prednisolone. In addition, 29% of the intervention group had fractures, versus 11% of controls.
The PRAC also confirmed its previous interim recommendation that Xofigo must not be used with abiraterone acetate and prednisone/prednisolone.