Adverse Effects of Low-Dose Methotrexate: A Randomized Trial

Pre-specified safety analysis from Cardiovascular Inflammation Reduction Trial (n=6,158) shows relative rates of AEs were higher in those on methotrexate vs placebo group for gastrointestinal AE, liver enzyme elevations, pulmonary AEs, infectious events, anaemia and leukopenia.

SPS commentary:

In a related editorial, the author notes that while data pertaining to adverse effects associated with methotrexate is predominantly based on meta-analyses of observational data, this study provides updated estimates of risk.


Annals of Internal Medicine

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