Alkindi (hydrocortisone granules): risk of acute adrenal insufficiency in children when switching from hydrocortisone tablet formulations to granules

Adrenal crisis has been reported in an infant switched from hydrocortisone soluble tablets to Alkindi. When children on replacement therapy for adrenal insufficiency (AI) are being switched, parents or carers should be informed of the need to be extra vigilant for symptoms of AI.

Source:

Medicines and Healthcare products Regulatory Agency