All-Cause and Cause-Specific Mortality Among People Using Extramedical Opioids: A Systematic Review and Meta-analysis

Review (124 cohort studies) found extramedical opioids linked to significant excess mortality (MT), much of which is preventable. Pooled all cause crude MT rate (99 studies, n=1,262,592) was 1.6/100 person-years and pooled all-cause standardised MT ratio (43 cohorts) was 10.


JAMA Psychiatry