Antidepressants for smoking cessation

This updated review (115 studies; 33 new) found high-certainty evidence that bupropion increased long-term smoking cessation rates (RR 1.64, 95% CI 1.52 to 1.77). Nortriptyline also appears to have a beneficial effect on smoking quit rates relative to placebo (2.03, 1.48 to 2.78)

SPS commentary:

There is evidence that bupropion may be as successful as NRT (RR 0.99, 0.91 to 1.09) but inferior to varenicline (0.71, 0.64 to 0.79) for smoking cessation rates. The authors comment that further studies investigating the efficacy of bupropion versus placebo are unlikely to change their interpretation of the effect, providing no clear justification for pursuing it for smoking cessation over front-line smoking cessation aids already available.

Cochrane Database of Systematic Reviews