Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial

RCT (n=587) reports olanexidine significantly reduced surgical site infection at 30 days; 19 (7%) patients in olanexidine group vs 39 (13%) in povidone-iodine group (adjusted risk ratio 0.48, 90% CI 0.30 to 0.74; p=0.002).

SPS commentary:

Authors of a related commentary state the study cannot be used to derive grade A recommendation because investigators originally planned to use a 95% CI, but used 90% CI instead.


The Lancet Infectious Diseases

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