Assessment of Acute Acral Lesions in a Case Series of Children and Adolescents During the COVID-19 Pandemic

Prospective case series of 20 patients with new-onset inflammatory lesions of acral skin disease referred to a teritiary centre reports that, none had remarkable haematologic/serologic abnormalities, and no evidence was found to support the implication of SARS-CoV-2 infection.

SPS commentary:

Authors of this study highlight that during the COVID-19 pandemic, several cases of acral lesions and other similar skin conditions have been reported in infected patients. There have been suspicions that this may be a potential manifestation of the disease. 

Authors of a related commentary state testing needs to occur in larger numbers and also at different stages of the disease to determine if a low viral load, undetectable with current methods, or the inability to mount an adequate immune response accounts for the negative SARS-CoV-2 test results. Authors recommend dermatologists be aware of the protean cutaneous findings that are possibly associated with COVID-19, even if understanding of their origins remains incomplete at this time.

A second case series by Herman and colleagues (n=31) reports similar findings, and has been published in the same edition of this journal.


JAMA Dermatology

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Herman et al series: