Association Between Drug Use and Subsequent Diagnosis of Lupus Erythematosus

In case-control study (n=3148 & 31,480 controls), many significant associations were found between use of a variety of drugs and a subsequent diagnosis of cutaneous lupus erythematosus (CLE) or SLE, including some new plausible causal associations.

SPS commentary:

New plausible causal associations were observed between CLE or SLE and some drugs, including fexofenadine, levothyroxine sodium, metoclopramide and metronidazole. Study advises that consideration should be given to a newly diagnosed case of CLE or SLE potentially being drug induced.


JAMA Dermatology