Association Between Prehospital Tranexamic Acid Administration and Outcomes of Severe Traumatic Brain Injury

Prospective study (n=1,827) found prehospital tranexamic acid increased mortality in patients with isolated severe traumatic brain injury (OR 4.49; 95% CI, 1.57-12.87; p=0.005), highlighting need for judicious use of the drug when there is no evidence for extracranial haemorrhage

JAMA Neurology