Association of Low-Dose Triple Combination Therapy With Therapeutic Inertia and Prescribing Patterns in Patients With Hypertension A Secondary Analysis of the TRIUMPH Trial

Analysis (n=700) found low-dose triple antihypertensive therapy (telmisartan 20mg, amlodipine 2.5mg, chlorthalidone 12.5 mg) improves BP control & simplifies treatment regimen but is linked to increased therapeutic inertia (not intensifying therapy in those with BP above target).

SPS commentary:

In the study, 221 of 318 [69.5%] in triple pill group vs 182 of 329 [55.3%] usual care group, achieved BP pressure targets and respective rates of therapeutic inertia at week 6 visit were 86.8% (92 of 106) vs 63.9% (124 of 194) and 90% (81 of 90) vs 64.8% (116 of 179) at week 12 visit.

JAMA Cardiology