Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women

Study in 27,858 female healthcare professionals age >45 years found an increased risk of CVD events in patients who had a migraine with aura vs those with migraine without an aura or no migraine (3.336 vs 2.11 events/1000 person years, p<0.001).

SPS commentary:

The incidence rate for women with migraine with aura was significantly higher than the adjusted incidence rate among women with obesity, high triglycerides, or low high-density lipoprotein cholesterol, but was not significantly different from the rates among those with elevated systolic blood pressure, high total cholesterol, or family history of myocardial infarction. Incidence rates among women with diabetes or who currently smoked were significantly higher than those with migraine with aura.

Authors highlight that the clinical importance of these findings, and whether they are generalizable beyond this study population, require further research.

Journal of the American Medical Association