Bupropion and Naltrexone in Methamphetamine Use Disorder

RCT (n=403) found response (≥3 methamphetamine-negative urine samples out of 4) over 12 weeks among those on extended-release injectable naltrexone plus oral extended-release bupropion was low, but higher than in placebo group (weighted average response 13.6% vs. 2.5%; p<0.001).

Source:

New England Journal of Medicine