Cancer and Leukemia Group B 90203 (Alliance): Radical Prostatectomy With or Without Neoadjuvant Chemohormonal Therapy in Localized, High-Risk Prostate Cancer

RCT (n=788) found no improvement in 3-year progression free survival, but an increase in grade 3 or 4 adverse events when patients were given chemohormonal therapy in addition to radical prostatectomy vs surgery alone.

Journal of Clinical Oncology