ChaMP-CMD: A Phenotype-Blinded, Randomized Controlled, Cross-Over Trial

RCT (87 people with angina & nonobstructive coronary arteries) found both amlodipine & ranolazine increased treadmill exercise time more in those with coronary microvascular disease (CMD) vs without CMD (diff. = +82s, p<0.001 for amlodipine & +68s p=0.005 for ranolazine).

SPS commentary:

Authors conclude the findings support measurement of coronary flow reserve to diagnose and guide use of anti-ischaemic agents in patients with angina with nonobstructive coronary arteries.

Circulation