Characteristics and Strength of Evidence of COVID-19 Studies Registered on ClinicalTrials.gov

Study (1,551 studies) found that despite the marked rise in COVID-19 studies; only 29.1% of those registered have the potential to result in acceptable level 2 evidence on the 2011 Oxford Centre for Evidence-Based Medicine level of evidence framework.

SPS commentary:

In an Editor’s note, the authors’ state global decline in new cases could also stall enrollment; and even before results are known, most studies will not likely yield meaningful scientific evidence at a time when rapid generation of high-quality knowledge is critical.

JAMA Internal Medicine

Resource links:

Editor's note