Chlorhexidine plus alcohol versus povidone iodine plus alcohol, combined or not with innovative devices, for prevention of short-term peripheral venous catheter infection and failure (CLEAN 3 study): an investigator-initiated, open-label, single centre, randomised-controlled, two-by-two factorial trial

RCT (n=1000, France) found chlorhexidine and alcohol provides greater protection against catheter-related infectious complications than povidone iodine and alcohol (0 vs 1%) and innovative devices extended catheter complication-free dwell time (50.4 vs. 30 hrs; p=0.0017).

Source:

The Lancet Infectious Diseases