Clinical Picture: Pulmonary embolism and thrombocytopenia following ChAdOx1 vaccination
Report describes 51-year-old woman with 3-day history of dyspnoea, fatigue, and cough, who has had ChAdOx1 nCoV-19 vaccination 11 days earlier. Lab investigations showed a severe thrombocytopenia and CT pulmonary angiography showed a central pulmonary embolism
Source:
The Lancet
SPS commentary:
The authors note that the activation of the coagulation system producing thromboses in the context of thrombocytopenia and hypofibrinogenaemia—as occurred in this patient—is similar to heparin-induced thrombocytopenia and to that seen in critically ill COVID-19 patients.