Comparison of 3 Treatment Strategies for Medication Overuse Headache: A Randomized Clinical Trial

Open label RCT (n=120) found an increased chance of medication overuse headache cure using a strategy of withdrawal plus prevention treatment (96.8%) vs prevention treatment alone (74.3%) and withdrawal treatment alone (88.9%).

SPS commentary:

Authors highlight that all 3 treatment strategies were effective, but based on these findings, withdrawal therapy combined with preventive medication from the start of withdrawal is the preferred treatment.

JAMA Neurology