COVID-19 pathophysiology: looking beyond acute disease

A Series of four papers highlights the wealth of data pertaining to the pathophysiology of acute disease that has emerged over the past year, but emphasises that many uncertainties about the mechanisms of acute disease and potential targets for intervention remain.

SPS commentary:

The Series features the following articles:

  • The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
  • Interleukin-6: obstacles to targeting a complex cytokine in critical illness
  • Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context
  • A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19

The Lancet Respiratory Medicine

Resource links:

COVID-19 puzzle

Interleukin-6: obstacles

Interleukin-6 receptor blockade

Tricompartmental model