Dabigatran trough concentrations in very elderly patients

Observational study of 75 patients with atrial fibrillation, found trough concentrations were considerably higher in the highest age category. Dose-normalised medians were 0.66, 0.83 and 1.20 ng/mL/mg in the <75, 75–84 and ≥85 age groups, respectively (p=0.004).

SPS commentary:

Researchers note clinicians should be aware of higher dabigatran concentrations in elderly patients despite dose reduction.

European Journal of Hospital Pharmacy