Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials

This review of 10 studies (n=2,143) found no difference in 28-day mortality between delayed and early initiation of renal replacement therapy (RRT) in critically ill adults, in the absence of urgent indications for RRT (44% v 43%; risk ratio 1.01; 95% CI 0.91-1.13; p=0.80).

Source:

The Lancet