Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

RCT (n=1775) concludes in people with type 2 diabetes and normoalbuminuria, a high-risk score from the urinary proteomic classifier CKD273 was associated with increased risk of progression to microalbuminuria over median of 2.5yrs, and spironolactone did not prevent progression.

SPS commentary:

In a related editorial, the author discusses the use of non-invasive urinary biomarkers for early diagnosis, disease progression, and response to therapy in people with diabetes.


The Lancet Diabetes & Endocrinology

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