Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial
2x2 factorial RCT (n=824) found lower dose (35-50mg/kg/d) was non-inferior to higher dose (70-90mg/kg/day) amoxicillin in terms of retreatment requirement at 28 days (12.6% vs 12.4%). Shorter 3 day courses were also non-inferior to 7 day courses (12.5% vs 12.5%).
Source:
Journal of the American Medical Association
SPS commentary:
Authors state however disease severity, treatment setting, prior antibiotics received, and acceptability of the noninferiority margin (8%) require consideration when interpreting the findings.