Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: The OPTIMISE Randomized Clinical Trial

RCT (n=569) found that in older patients treated with multiple antihypertensives, a strategy of medication reduction was non-inferior to usual care for systolic blood pressure control (86.4% and 87.7% had systolic BP <150mmHg respectively, RR 0.98, p<0.05).

SPS commentary:

Authors highlight that although the findings suggest antihypertensive medication reduction in some older patients with hypertension is not associated with substantial change in blood pressure control, further research is needed to understand long-term clinical outcomes.


A related commentary discusses this research and highlights other research that should be considered when defining optimal strategies for blood pressure control ion older patients.


Journal of the American Medical Association

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