Effect of antimicrobial therapy on respiratory hospitalization or death in adults with idiopathic pulmonary fibrosis: The CleanUP-IPF randomized clinical trial
In this pragmatic RCT (n=513) the addition of co-trimoxazole or doxycycline to usual care did not reduce rate of first nonelective respiratory hospitalisation or death (20.4 vs 18.4 events per 100 person-years; p=0.83).
Source:
Journal of the American Medical Association