Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial

RCT (n=370) found that, among patients with moderate/ severe traumatic brain injury, continuous infusion of 20% hypertonic saline did not improve neurological status vs standard care. However it may not have been sufficiently powered to detect a clinically important difference.

Journal of the American Medical Association