Effect of cytisine vs varenicline on smoking cessation. A Randomized Clinical Trial
RCT (n=1452) failed to demonstrate noninferiority of cytisine vs varenicline regarding smoking cessation. Verified 6-month continuous abstinence rates were 11.7% for cytisine group vs 13.3% for varenicline group (risk difference, −1.62% [97.5% CI, −5.02% to ∞].
Source:
Journal of the American Medical Association
SPS commentary:
Varenicline products are currently unavailable in the UK (see MHRA supply disruption alert). Cytisine is not licensed in the UK.