Effect of cytisine vs varenicline on smoking cessation. A Randomized Clinical Trial

RCT (n=1452) failed to demonstrate noninferiority of cytisine vs varenicline regarding smoking cessation. Verified 6-month continuous abstinence rates were 11.7% for cytisine group vs 13.3% for varenicline group (risk difference, −1.62% [97.5% CI, −5.02% to ∞].

SPS commentary:

Varenicline products are currently unavailable in the UK (see MHRA supply disruption alert). Cytisine is not licensed in the UK.

Source:

Journal of the American Medical Association

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