Effect of Gonadotropin-Releasing Hormone Antagonist on Risk of Committing Child Sexual Abuse in Men With Pedophilic Disorder: A Randomized Clinical Trial

Swedish trial (n=52) found 2 subcutaneous injections of 120mg degarelix acetate reduced risk score for committing child sexual abuse in men with paedophilic disorder 2 weeks after initial injection vs. placebo (from 7.4 to 4.4 vs 7.8 to 6.6, respectively;difference -1.8;p =0 .01)

SPS commentary:

An editorial notes the most important long-term outcome criterion is the reduction in recidivism in high-risk individuals, which was not addressed in this study, and nor could it address long-term adverse effects. However, it considers this study the most important contribution to the field of pharmacotherapy of paedophilic disorders since Rösler and Witztum’s study on GnRH-agonists in 1998.


JAMA Psychiatry

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