Effect of high-dose baclofen on agitation-related events among patients with unhealthy alcohol use receiving mechanical ventilation

RCT (n=314) found a statistically significant reduction in agitation-related events in these patients treated with high-dose baclofen (50-150mg) vs placebo (19.7% vs 29.7%). Further research needed to determine role and optimise dosing of baclofen in this setting.

Journal of the American Medical Association