Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial

RCT (n=18,353) found that, among adults without depressive symptoms, treatment with vitamin D3 vs placebo did not result in a significant difference in the incidence and recurrence of depression or clinically relevant depressive symptoms or change in mood scores.


Journal of the American Medical Association