Effect of Recombinant Human Parathyroid Hormone (1-84) on Resolution of Active Charcot Neuro-osteoarthropathy in Diabetes: A Randomized, Double-Blind, Placebo-Controlled Study

Fractures in Charcot neuro-osteoarthropathy often fail to heal despite prolonged immobilisation with below-knee casting. RCT (n=48) found recombinant human PTH (1-84) did not reduce time to resolution or enhance fracture healing vs. placebo (median 5 vs. 6 months, respectively).

Diabetes Care