Effect of renal function on the risk of thrombocytopenia in patients receiving linezolid therapy: a systematic review and meta-analysis

Review (24 studies;n=3580) found impaired renal function linked to increased risk of linezolid-induced thrombocytopenia (OR 4.15; 95% Cl 2.85-6.03) suggesting a reduced dose may be considered in renally impaired patients at low risk of treatment failure, ideally guided by TDM

British Journal of Clinical Pharmacology