Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free Days in patients with sepsis

RCT (n=501) found no significant increase of ventilator- and vasopressor-free days with vitamin C, thiamine and hydrocortisone treatment vs placebo in critically ill patients with sepsis. Trial terminated early for administrative reasons and may have been underpowered.

Journal of the American Medical Informatics Association