Effectiveness of angiotensin-neprilysin inhibitor treatment versus renin-angiotensin system blockade in older adults with heart failure in clinical care

US cohort study (n=51,208) found the use of an angiotensin receptor-neprilysin inhibitor (ARNIs) reduced risk of the composite endpoint of worsening heart failure and all-cause mortality by 16% vs renin-angiotensin system blockade alone (HR 0.84, 95%CI 0.80-0.89).

Heart