Effects of thyroid-stimulating hormone suppression after thyroidectomy for thyroid cancer on bone mineral density in postmenopausal women: a systematic review and meta-analysis

Analysis (16 case-control studies) found stringent TSH suppression (TSH <0.10 mIU/L) after thyroidectomy had deleterious effects on lumbar spine BMD (standardised mean difference −0.55 v controls; 95% CI −0.99 to −0.10) but no statistically significant effect on femoral neck BMD

SPS commentary:

Lower degrees of TSH suppression (TSH 0.10–0.49 mIU/L) were not associated with a reduction in lumbar spine BMD in this population. The authors note that further studies are required to determine whether the observed lower BMD associated with stringent TSH suppression after thyroidectomy in postmenopausal women is associated with an increased risk of fractures.

BMJ Open