Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial

In RCT (n=132) terminated early, daily hydroxychloroquine did not prevent SARS-CoV-2 infection (infection rates of 4 of 64 [6.3%] vs 4 of 61 [6.6%] placebo; p > 0.99). It may have been underpowered to detect a clinically important difference due to early termination.

Source:

JAMA Internal Medicine