Efficacy and Safety of Phentermine/Topiramate in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis

Review of 6 studies found phentermine/topiramate use had an incremental weight loss of 7.73kg (p<0.05) vs placebo. The RR for achieving ≥5%, ≥10%, and ≥15% weight loss from baseline vs placebo was 3.18 (95%CI 2.75-3.67), 5.32 (4.53-6.25) and 5.65 (3.55-9.01) respectively.

Obesity