Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001

RCT (n=239) found a regimen of calaspargase every 3 weeks had a similar nadir, serum asparaginase activity, toxicity and survival outcomes vs pegaspargase every 2 weeks. Authors highlight the high nadir in both arms suggests dosing strategies can be optimised.

Source:

Journal of Clinical Oncology