Efficacy of vitamin D3 supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial

RCT (n=4000,Tanzania) found no overall effect of oral vitamin D3 supplementation (50 000 IU weekly 1st month then 2000 IU/d) on risk of mortality vs placebo (HR 1.04, 95% CI 0.85–1.25; p=0.73) and there was no difference in overall TB incidence (0.78, 0.54–1.13; p=0.19) at 1 year


The Lancet HIV