Loxapine should only be administered in a hospital-setting under the supervision of a healthcare professional. The recommended initial dose o is 9.1 mg. A second dose can be given after 2 hours, if necessary. No more than two doses should be administered. Patient should be observed during the first hour after each dose for signs and symptoms of bronchospasm and a short-acting beta-agonist bronchodilator should be available in case this reaction occurs.