Manufacturers therefore advise that they should only be used after careful benefit-risk assessment in patients with a previous history or family history of aortic aneurysm, or in the presence of other risk factors of aortic aneurysm and dissection (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, Takayasu arteritis, giant cell arteritis, Behcet’s disease, hypertension, known atherosclerosis).