Revised SPC: Coversyl Arginine (perindopril arginine)

There are new contraindications (bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney, extracorporeal treatments and use with sacubitril/valsartan), and an interaction with co-trimoxazole (concomitant use may increase risk of hyperkalaemia).

Further new information includes the following:

 

·         Use is not recommended in patients with primary aldosteronism

·         Cases of SIADH (syndrome of inappropriate antidiuretic hormone secretion) have been reported with other ACE inhibitors. SIADH can be considered as a very rare but possible complication associated with ACE inhibitor therapy including perindopril.