SPC details that concomitant administration of non-live vaccines according to national vaccination schedules may be considered during therapy with dimethyl fumarate.
No clinical data are available on the efficacy and safety of live attenuated vaccines in patients taking dimethyl fumarate. Live vaccines might carry an increased risk of clinical infection and should not be given to patients treated with dimethyl fumarate. unless, in exceptional cases, this potential risk is considered to be outweighed by the risk to the individual of not vaccinating.