Revised SPC: Timoptol (timolol) 0.25% and 0.5% w/v Eye Drops Solution -

Revised SPC: Timoptol (timolol) 0.25% and 0.5% w/v Eye Drops Solution
Information type: Drug prescribing
Source: electronic Medicines compendium
Specialities: Eyes and vision
Summary
SPC now warns benzalkonium chloride has been reported to cause eye irritation, symptoms of dry eyes and may affect tear film and corneal surface. It should be used with caution in dry eye patients and in patients where cornea may be compromised. Prolonged use should be monitored.
UKMi comment
SPC also notes that cases of corneal calcification have been reported very rarely in association with the use of phosphate containing eye drops in some patients with significantly damaged corneas.
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