Revised SPC: Topamax (topiramate) -

Revised SPC: Topamax (topiramate)
Information type: Drug prescribing
Source: electronic Medicines compendium
Specialities: Family planning | Neurological disorders | Obstetrics and gynaecology
Summary
Before initiating topiramate in a woman of childbearing potential, pregnancy testing should be performed and a highly effective contraceptive method advised. The patient should be fully informed of the risks related to the use of topiramate during pregnancy.
UKMi comment
This recommendation is based on a study which suggested an approximate 3‑fold higher prevalence of major congenital malformations in pregnant women taking topiramte compared with a reference group not taking antiepileptic drugs
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