Everolimus cannot be used due to lack of suitable dose stregths for adjustments.
Where concomitant use with tacrolimus or sirolimus cannot be avoided it advises withholding tacrolimus or sirolimus on the day of Viekirax or dasabuvir initiation, and reinstating the day after at a reduced dose based on levels. Tacrolimus or sirolimus whole blood concentrations should be monitored upon initiation and throughout coadministration with Viekirax and dasabuvir and the dose and/or dosing frequency should be adjusted as needed. Patients should be monitored frequently for any changes in renal function or tacrolimus or sirolimus associated adverse events.