Acid-sensing ion channel (ASIC) 3 has been shown to be a neuronal sensor for appropriate adjustment to pressure in the cutaneous microcirculation protecting healthy skin against pressure ulcers in animal models. Besides its diuretic properties, amiloride has been found to be an inhibitor of ASICs, therefore, his this study investigated the hypothesis that in patients treated with amiloride, the physiological protection of the skin against pressure might be impaired.