Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy -

Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy
Information type: Other primary research
Source: Neurology
Specialities: Stroke
Summary
This subgroup analysis suggests that clopidogrel plus aspirin vs. aspirin alone improves 90-day functional outcome (poor functional outcome occurred in 254 [9.9%] on combination vs 299 [11.6%] on aspirin alone; p=0.046) in patients with acute minor stroke or TIA.
UKMi comment
The primary analysis of the CHANCE trial had found that combined treatment of clopidogrel and aspirin decreases 90-day risk of stroke without increasing haemorrhage in comparison with aspirin alone. A further analysis found that the early benefit of clopidogrel-aspirin treatment in reducing the risk of subsequent stroke persisted for the duration of 1-year of follow-up.
Related links: Primary analysis One year follow up